Njengesixhobo esisisiseko sokuxilonga, i-depressants yolwimi, ngelixa ibonakala ilula, igcina imfuno ezinzileyo kwiimarike zezixhobo zonyango. Kwiminyaka yakutshanje, ngokuphuculwa kwemigangatho yonyango yehlabathi kunye nokwandiswa kweemarike ezikhulayo, imboni yokudambisa ulwimi ibonise iindlela ezintsha zophuhliso.
Ngokombono wezinto eziphathekayo, abacinezeli bolwimi lweplanga besintu basenesabelo esibalulekileyo semarike, kodwa iinkxalabo zokusingqongileyo kunye nococeko ziye zaqhuba ukuthandwa kweplastiki elahlayo kunye nezicinezeli zolwimi zentsimbi. Izinto ezilahlwayo zokuxinzelela ulwimi zifunwa ngamandla kumazwe aphuhlileyo afana neYurophu kunye neMelika ngenxa yokulungela kwazo kunye nokukwazi ukunqanda ukosuleleka{1}}, ngelixa izicinezeli zolwimi eziphinda zisebenziseke kwintsimbi engenastainless zigcina ukukhula okuzinzileyo kumazwe asakhulayo ngenxa yokuqina kwazo kunye neenzuzo zeendleko.
Kwihlabathi jikelele, iimfuno ezingqongqo zokuthotyelwa kwezonyango zinyanzela abavelisi boxinzelelo lolwimi ukuba babeke ugxininiso olukhulu kwizatifikethi zomgangatho wemveliso, ezinje nge-FDA kunye nemigangatho ye-CE, ethe yaba yimiqobo ephambili yokungena kwimarike yamazwe ngamazwe. Ngaphaya koko, ukusetyenziswa kobuchwepheshe bemveliso obuzenzekelayo buphucule ukusebenza kakuhle kwemveliso yokucinezela ulwimi, ukucutha iindleko zabasebenzi, kunye nokukhuthaza ukuthengisa ngaphandle okukhulu{1}}.
Ukuphuculwa ngokuthe ngcembe kweziseko zonyango kwiimarike ezisakhulayo ezifana ne-Asia-mpuma ye-Asia, i-Afrika kunye ne-Latin America kukhokelele ekunyukeni okuqhubekayo kwemfuno yezixhobo zonyango ezisisiseko, ukubonelela ngamathuba amatsha okukhula okuthunyelwa kwe-depressor yolwimi kumazwe angaphandle. Ngaxeshanye, ukunyuka -kwemida ye-e{2}}kurhwebo lubonelele ababoneleli abancinci nabaphakathi{3}}abanobungakanani bokufikelela kwimakethi yamazwe ngamazwe, kuthotywa imiqobo kurhwebo lwangaphandle.
Kwixesha elizayo, ishishini lokucinezela ulwimi liya kuphuhla kwindawo ekhuselekileyo, ehambelana nokusingqongileyo, kunye nesikhokelo esisebenzayo. Abavelisi kufuneka babeke iliso kutshintsho kwimigangatho yamazwe ngamazwe, baphucule iinkqubo zemveliso, kwaye basebenzise iindlela ezahlukeneyo zemveliso ukuhlangabezana neemfuno ezahlukeneyo zemarike. Kubasebenzi borhwebo bangaphandle, ukuqonda iintsingiselo zeemarike zengingqi kunye neemfuno zesatifikethi kuya kuba ngundoqo ekuthabatheni amathuba kwishishini lokudambisa ulwimi.